Recombinant Human TGFBR2 protein (His tag)
Product Specifications
Background
TGFBR2 is a single-pass type I membrane protein and contains one protein kinase domain. TGFBR2 exsits as a heterodimeric complex with another receptor protein and binds TGF-beta. Signals triggered through the TGF-beta receptor complex prompt various responses by the cell. One such response is to inhibit cell growth and division. Based on this action, the TGF-beta receptor type 2 is sometimes called a tumor suppressor. Defects in TGFBR2 have been associated with Marfan syndrome, Loeys-Deitz aortic aneurysm syndrome, Osler-Weber-Rendu syndrome and the development of various types of tumors.
Abbreviation
TGFBR2
Synonyms
AAT3; FAA3; LDS1B; LDS2; LDS2B; MFS2; RIIC; TAAD2; TGF-beta receptor type-2; TGF-beta type II receptor; TGFBR2; TGFR-2; TGFbeta-RII; Transforming growth factor-beta receptor type II
UniProt
P37173
Accession Number
P37173
Expression System
E.coli
Tag
N-His
Sequence
Thr 23-Gln 166
Field of Research
Signal Transduction; Stem cells
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/44gxdk
Product MSDS
https://789.bio/eb/W1RRxP
Calculated Molecular Weight
15.7 kDa
Observed Molecular Weight
25 kDa
Species
Human
Available Sizes
Curated Selection
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