Recombinant Human PIK3CA Protein (His Tag)
Product Specifications
Background
Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns (4,5) P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. A pseudogene of this gene has been defined on chromosome 22.
Abbreviation
PIK3CA
Synonyms
5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha;5-bisphosphate 3-kinase catalytic subunit alpha isoform; CLOVE; CWS5; MCAP; MCM; MCMTC; MGC142161; MGC142163; Phosphatidy; Phosphatidylinositol 3 kinase catalytic alpha polypeptide; caPI3K; p110 alpha; p110alpha
UniProt
P42336
Accession Number
P42336-1
Expression System
E.coli
Tag
N-His
Sequence
Met1-Pro200
Field of Research
Signal Transduction, Cancer, Immunology
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 90% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/cphoz1
Product MSDS
https://789.bio/eb/diy9hS
Calculated Molecular Weight
23.1 kDa
Observed Molecular Weight
25.4 kDa
Species
Human
Available Sizes
Curated Selection
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