HS024 (TFA)

HS024 is a selective MC4 receptor antagonist, with Kis of 0.29, 3.29, 5.45, 18.6 nM for MC4, MC5, MC3, and MC1, respectively. HS024 increase food intake[1].

Product Specifications

UNSPSC

12352209

Target

Melanocortin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/hs024-tfa.html

Purity

99.80

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

CCCC[C@@H]1NC([C@@H](NC(C)=O)CSSC[C@@H](C(N)=O)NC(CNC([C@@H](NC([C@@H](NC([C@H](NC([C@@H](NC([C@@H](NC1=O)CCCNC(N)=N)=O)CC2=C[N]C=N2)=O)CC3=CC4=C(C=CC=C4)C=C3)=O)CCCNC(N)=N)=O)CC5C=NC6=C5C=CC=C6)=O)=O)=O.O=C(O)C(F)(F)F

Molecular Formula

C60H80F3N19O12S2

Molecular Weight

1380.52

References & Citations

[1]Kask A, et al. Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024) : evaluation in vitro and in vivo. Endocrinology. 1998;139 (12) :5006-5014.