CAY10512

CAY10512 is a NF-κB inhibitor. CAY10512 can suppress the upregulation of NF-κB-sensitive proinflammatory miRNAs (miRNA-9, miRNA-125b, miRNA-146a, miRNA-155) in cerebrospinal fluid and extracellular fluid. CAY10512 significantly reduces the release of pro-inflammatory cytokines (such as TNF-α, MCP-1, IL-8, IL-6) . CAY10512 can be used for researchs on neuroinflammation, islet transplantation and microRNA regulation[1][2][3].

Product Specifications

CAS Number

[139141-12-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Interleukin Related; NF-κB; TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cay10512.html

Purity

97.0

Solubility

10 mM in DMSO

Smiles

COC(C=C1)=CC=C1/C=C/C2=C(C=CC=C2)F

Molecular Formula

C15H13FO

Molecular Weight

228.26

Precautions

H302, H315, H319, H335

References & Citations

[1]Alexandrov P N, et al. microRNA (miRNA) speciation in Alzheimer’s disease (AD) cerebrospinal fluid (CSF) and extracellular fluid (ECF) [J]. International journal of biochemistry and molecular biology, 2012, 3 (4) : 365.|[2]Kanak MA, et al. Alleviation of instant blood-mediated inflammatory reaction in autologous conditions through treatment of human islets with NF-κB inhibitors. Transplantation. 2014 Sep 15;98 (5) :578-84.|[3]Chantong B, et al. Mineralocorticoid and glucocorticoid receptors differentially regulate NF-kappaB activity and pro-inflammatory cytokine production in murine BV-2 microglial cells. J Neuroinflammation. 2012 Nov 28;9:260.