Venturicidin A

Venturicidin A (Aabomycin A1), from actinomycetes, is a membrane-active natural product inhibitor of ATP synthase. Venturicidin A potentiates the aminoglycoside antibiotic gentamicin against multidrug-resistant clinical isolates of Staphylococcus, Enterococcus, and Pseudomonas aeruginosa. Venturicidin A shows noticeable toxicity toward human embryonic-kidney (HEK) cells with an IC50 of 31 μg/mL.

Product Specifications

CAS Number

[33538-71-5]

Product Name Alternative

Aabomycin A1

UNSPSC

12352005

Hazard Statement

H302

Target

Antibiotic; ATP Synthase

Type

Natural Products

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/venturicidin-a.html

Purity

96.6

Solubility

DMSO : 8 mg/mL (ultrasonic; warming)

Smiles

CC1=CC[C@](O)(C2)O[C@]1([H])/C(C)=C\CCC[C@](O[C@@]3([H])C[C@H]([C@H](O)[C@@H](C)O3)OC(N)=O)([H])/C=C/[C@H](C)C[C@@H](C)[C@]([C@H](C)C[C@@H](C)[C@H](O)[C@H](C)C(CC)=O)([H])OC2=O

Molecular Formula

C41H67NO11

Molecular Weight

749.97

Precautions

H302

References & Citations

[1]Venkateswarlu Yarlagadda, et al. Venturicidin A, A Membrane-active Natural Product Inhibitor of ATP synthase Potentiates Aminoglycoside Antibiotics. Sci Rep. 2020 May 18;10 (1) :8134.