WBC100

WBC100 (14-D-Valine-TPL) is a potent, selective, and orally active c-Myc molecule glue degrader. WBC100 is a c-Myc degrader and targets ubiquitin E3 ligase CHIP mediated 26S proteasome pathway. WBC100 is used for c-Myc overexpressing tumors research[1].

Product Specifications

CAS Number

[2095780-08-6]

Product Name Alternative

14-D-Valine-TPL

UNSPSC

12352005

Target

C-Myc; Molecular Glues

Type

Reference compound

Related Pathways

Apoptosis; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/wbc100.html

Purity

95.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@]([C@@]1([H])C2)(CCC3=C1COC3=O)[C@]4([C@@]([C@@](O5)([H])[C@@]65C(C)C)([H])O4)[C@@]7([C@@]2([H])O7)[C@@H]6OC([C@H](N)C(C)C)=O

Molecular Formula

C25H33NO7

Molecular Weight

459.53

References & Citations

[1]Ying Xu, et al. A Selective Small-Molecule c-Myc Degrader Potently Regresses Lethal c-Myc Overexpressing Tumors. Adv Sci (Weinh) . 2022 Mar;9 (8) :e2104344.