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AZD-4818

AZD-4818 is a potent, orally active antagonist of chemokine CCR1. AZD-4818 can be used for researching chronic obstructive pulmonary disease (COPD) [1].

Product Specifications

UNSPSC

12352005

Target

CCR

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/azd-4818.html

Purity

99.10

Solubility

DMSO : 50 mg/mL (ultrasonic; adjust pH to 2 with HCl)

Smiles

CNC(C(C=C(C(OC(C)(C)C(O)=O)=C1)Cl)=C1OC[C@@H](O)CN2CCC3(CC2)OC4=CC=C(Cl)C=C4C3)=O

Molecular Formula

C27H32Cl2N2O7

Molecular Weight

567.46

References & Citations

[1]Norman P. AZD-4818, a chemokine CCR1 antagonist: WO2008103126 and WO2009011653. Expert Opin Ther Pat. 2009;19 (11) :1629-1633.|[2]Kerstjens HA, et al., Tolerability and efficacy of inhaled AZD4818, a CCR1 antagonist, in moderate to severe COPD patients. Respir Med. 2010 Sep;104 (9) :1297-303.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-15545/AZD-4818-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-15545/AZD-4818-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

Phase 2

Isoform

CCR1

CAS Number

[1003566-93-5]

Available Sizes

Curated Selection

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