LW6

LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor with an IC50 value of 4.4 μM, and it is also an inhibitor of MDH2. LW6 decreases HIF-1α protein expression without affecting HIF-1β expression.

Product Specifications

CAS Number

[934593-90-5]

Product Name Alternative

HIF-1α inhibitor; LW8

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; HIF/HIF Prolyl-Hydroxylase

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/LW6.html

Purity

98.86

Solubility

DMF : 17.24 mg/mL (ultrasonic) |DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(OC)C1=CC=C(O)C(NC(COC2=CC=C(C3(C4)CC5CC4CC(C5)C3)C=C2)=O)=C1

Molecular Formula

C26H29NO5

Molecular Weight

435.51

Precautions

H302, H315, H319, H335

References & Citations

[1]Naik R, et al. Synthesis and structure-activity relationship study of chemical probes as hypoxia induced factor-1α/malate dehydrogenase 2 inhibitors. J Med Chem. 2014 Nov 26;57 (22) :9522-38.|[2]Lee K, et al. LW6, a novel HIF-1 inhibitor, promotes proteasomal degradation of HIF-1alpha via upregulation of VHL in a colon cancer cell line. Biochem Pharmacol. 2010 Oct 1;80 (7) :982-9.|[3]Song JG, et al. Discovery of LW6 as a new potent inhibitor of breast cancer resistance protein.|[4]Sato M, et al. LW6, a hypoxia-inducible factor 1 inhibitor, selectively induces apoptosis in hypoxic cells through depolarization of mitochondria in A549 human lung cancer cells. Mol Med Rep. 2015 Sep;12 (3) :3462-8.