Fluorene

Fluorene is an orally active polycyclic aromatic hydrocarbon (PAH) and a precursor to other fluorene-based compounds. Fluorene and its derivatives serve as dye precursors for fluorene synthesis. In A549 cells, Fluorene induces oxidative stress and inflammatory responses by increasing ROS and SOD generation, exacerbating lipid peroxidation, modulating antioxidant enzyme activity, and upregulating the expression of pro-inflammatory factors TNF-α and IL-6. In vivo, Fluorene exhibits anxiolytic activity. Fluorene holds potential for research in inflammation and neurological disorders[1][2][3].

Product Specifications

CAS Number

[86-73-7]

UNSPSC

12171500

Hazard Statement

H360, H410

Target

Fluorescent Dye; Interleukin Related; Reactive Oxygen Species (ROS) ; SOD; TNF Receptor

Type

Dye Reagents

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/fluorene.html

Purity

99.35

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

C1(C=CC=C2)=C2CC3=C1C=CC=C3

Molecular Formula

C13H10

Molecular Weight

166.22

Precautions

H360, H410

References & Citations

[1]Paul Olusegun Bankole, et al. Biodegradation of fluorene by the newly isolated marine-derived fungus, Mucor irregularis strain bpo1 using response surface methodology. Ecotoxicol Environ Saf. 2021 Jan 15;208:111619.|[2]Guo H, et al. Oxidative stress and inflammatory effects in human lung epithelial A549 cells induced by phenanthrene, fluorene, and their binary mixture. Environ Toxicol. 2021 Jan;36 (1) :95-104.|[3]Peiffer J, et al. Behavioral toxicity and physiological changes from repeated exposure to fluorene administered orally or intraperitoneally to adult male Wistar rats: A dose–response study[J]. Neurotoxicology, 2016, 53: 321-333.