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DTRIM24

DTRIM24 is a selective bifunctional degrader of TRIM24 based on PROTAC, consists of ligands for von Hippel-Lindau and TRIM24.

Product Specifications

CAS Number

[2170695-14-2]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Epigenetic Reader Domain; PROTACs

Type

Reference compound

Related Pathways

Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dTRIM24.html

Purity

99.89

Solubility

DMSO : 100 mg/mL (ultrasonic) |Methanol : 150 mg/mL (ultrasonic)

Smiles

CN(C1=C2C=C(C(NS(C3=CC(C(NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@H](C4)O)C(NCC5=CC=C(C=C5)C6=C(N=CS6)C)=O)=O)=O)=O)=CC=C3)(=O)=O)=C1)OC7=CC=CC(OCCC)=C7)C(N2C)=O

Molecular Formula

C55H68N8O13S2

Molecular Weight

1113.30

Precautions

H315, H319, H320

References & Citations

[1]Gechijian LN, et al. Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands. Nat Chem Biol. 2018 Apr;14 (4) :405-412.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-111519/dTRIM24-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-111519/dTRIM24-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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