JSH-009
Product Specifications
UNSPSC Description
JSH-009 is a novel, highly selective CDK9 inhibitor critical for regulating transcription elongation. JSH-009 demonstrated significant in vitro and in vivo efficacy against acute myeloid leukemia (AML)[1].
Target Antigen
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer; Others
Assay Protocol
https://www.medchemexpress.com/jsh-009.html
Purity
99.21
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC[C@@H](C)N[C@@H](CC1)CC[C@H]1NC2=CC(C3=CSC(NCC4(CCOCC4)C#N)=N3)=C(Cl)C=N2
Molecular Weight
519.10
References & Citations
[1]Wang L, et al. Discovery of a novel and highly selective CDK9 kinase inhibitor (JSH-009) with potent antitumor efficacy in preclinical acute myeloid leukemia models. Invest New Drugs. 2020 Oct;38(5):1272-1281.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-X0009/JSH-009-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-X0009/JSH-009-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2247481-08-7
Available Sizes
Curated Selection
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