SJ000063181
SJ000063181 is a potent BMP signaling activator. SJ000063181 activates BMP4 and the phosphorylation of SMAD1/5/8 (p-SMAD1/5/8) . SJ000063181 induces ventralization in zebrafish embryos[1].
Product Specifications
CAS Number
[945189-68-4]
UNSPSC
12352005
Target
TGF-beta/Smad
Type
Reference compound
Related Pathways
Stem Cell/Wnt; TGF-beta/Smad
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/sj000063181.html
Purity
98.92
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(CC1=CC(C(NC2=CC(Cl)=C(F)C=C2)=O)=NO1)C
Molecular Formula
C14H14ClFN2O2
Molecular Weight
296.72
References & Citations
[1]Jamie R Genthe, et al. Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway. ACS Chem Biol.2019 Jul 19;14 (7) :1673.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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