SJ000063181

SJ000063181 is a potent BMP signaling activator. SJ000063181 activates BMP4 and the phosphorylation of SMAD1/5/8 (p-SMAD1/5/8) . SJ000063181 induces ventralization in zebrafish embryos[1].

Product Specifications

CAS Number

[945189-68-4]

UNSPSC

12352005

Target

TGF-beta/Smad

Type

Reference compound

Related Pathways

Stem Cell/Wnt; TGF-beta/Smad

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/sj000063181.html

Purity

98.92

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(CC1=CC(C(NC2=CC(Cl)=C(F)C=C2)=O)=NO1)C

Molecular Formula

C14H14ClFN2O2

Molecular Weight

296.72

References & Citations

[1]Jamie R Genthe, et al. Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway. ACS Chem Biol.2019 Jul 19;14 (7) :1673.