Amphotericin B methyl ester

Amphotericin B methyl ester is the methyl ester derivative of the polyene antibiotic Amphotericin B (A634250) . Amphotericin B methyl ester is the cholesterol-binding compound possesses significant antifungal activity. Amphotericin B methyl ester disrupts HIV-1 particle production and potently inhibits HIV-1 replication[1][2].

Product Specifications

CAS Number

[36148-89-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Fungal; HIV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/amphotericin-b-methyl-ester.html

Purity

96.19

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC([C@H]1[C@@]2([H])O[C@](O)(C[C@H](C[C@H]([C@@H](CC[C@H](C[C@H](CC(O[C@H]([C@@H]([C@H](O)[C@@H](C)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](O[C@@]3([H])[C@H]([C@H]([C@H](O)[C@@H](C)O3)N)O)C2)C)C)=O)O)O)O)O)O)C[C@@H]1O)=O

Molecular Formula

C48H75NO17

Molecular Weight

938.11

Precautions

H302, H315, H319, H335

References & Citations

[1]Waheed AA, et al. Inhibition of human immunodeficiency virus type 1 assembly and release by the cholesterol-binding compound amphotericin B methyl ester: evidence for Vpu dependence. J Virol. 2008 Oct;82 (19) :9776-81.|[2]Keim GR, et al. Comparative toxicological studies of amphotericin B methyl ester and amphotericin B in mice, rats, and dogs. ntimicrob Agents Chemother. 1976 Oct;10 (4) :687-90.