Sincalide

Sincalide (Cholecystokinin octapeptide, CCK-8) is a rapid-acting amino acid polypeptide hormone analogue of cholecystokinin (CCK) for intravenous use in postevacuation cholecystography. Sincalide is a major bioactive segment of CCK that retains most of the biological activities of CCK. Sincalide can promote gallbladder contraction by injection and helps diagnose gallbladder and pancreas disorders. Sincalide can increase bile secretion, cause the gallbladder to contract and relax the sphincter of Oddi, resulting in bile drainage into the duodenum. Sincalide is a major bioactive segment of CCK that retains most of the biological activities of CCK[1][2][3].

Product Specifications

CAS Number

[25126-32-3]

Product Name Alternative

Cholecystokinin octapeptide; CCK-8; SQ19844

UNSPSC

12352209

Hazard Statement

H302, H312, H332

Target

Akt; Apoptosis; Cholecystokinin Receptor; PI3K

Type

Peptides

Related Pathways

Apoptosis; GPCR/G Protein; Neuronal Signaling; PI3K/Akt/mTOR

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/Sincalide.html

Purity

99.00

Solubility

DMF : 50 mg/mL (ultrasonic) |DMSO : 25 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic; adjust pH to 11 with NH3·H2O)

Smiles

NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CNC2=C1C=CC=C2)NC(CNC([C@@H](NC([C@H](CC3=CC=C(C=C3)OS(=O)(O)=O)NC([C@H](CC(O)=O)N)=O)=O)CCSC)=O)=O)=O)CCSC)=O)CC(O)=O)=O)CC4=CC=CC=C4)=O

Molecular Formula

C49H62N10O16S3

Molecular Weight

1143.27

Precautions

H302, H312, H332

References & Citations

[1]Maher KA et al. Kinevac (sincalide for injection) /Squibb Diagnostics. Gastroenterol Nurs. 1991 Oct;14 (2) :98-100.|[2]Ziessman HA. Sincalide: A Review of Clinical Utility, Proper Infusion Methodology, and Alternative Cholecystogogues. J Nucl Med Technol. 2019 Sep;47 (3) :210-212.|[3]Can Wang, et al. Cholecystokinin octapeptide reduces myocardial fibrosis and improves cardiac remodeling in post myocardial infarction rats. Int J Biochem Cell Biol. 2020 Aug;125:105793.|[4]Can Wang, et al. Protective effect of cholecystokinin octapeptide on angiotensin II-induced apoptosis in H9c2 cardiomyoblast cells. J Cell Biochem. 2020 Jul;121 (7) :3560-3569.