Eliprodil

Eliprodil (SL-820715) is a non-competitive NR2B-NMDA receptor antagonist (IC50=1 uM), less potent for NR2A- and NR2C-containing receptors (IC50> 100 uM) . IC50 value: Target: NR2B-NMDA antagonist Human N-type Ca2+ channel currents were inhibited by ifenprodil and eliprodil with IC50 values of 50 microM and 10 microM respectively whereas P-type Ca2+ channel currents were inhibited reversibly by ifenprodil and eliprodil with approximate IC50 values of 60 microM and 9 microM respectively. eliprodil (1 microm) produced a moderate reverse rate-dependent prolongation of the action potential duration (7.4+/-1.5, 8.9+/-2.1 and 9.9+/-1.8% at cycle lengths of 300, 1000 and 5000 ms, respectively; n=9) .

Product Specifications

CAS Number

[119431-25-3]

Product Name Alternative

SL-820715

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Eliprodil.html

Purity

99.65

Solubility

DMSO : 14.29 mg/mL (ultrasonic)

Smiles

ClC(C=C1)=CC=C1C(O)CN(CC2)CCC2CC3=CC=C(F)C=C3

Molecular Formula

C20H23ClFNO

Molecular Weight

347.85

Precautions

H302, H315, H319, H335

References & Citations

[1]Bath CP, et al. The effects of ifenprodil and eliprodil on voltage-dependent Ca2+ channels and in gerbil global cerebral ischaemia. Eur J Pharmacol. 1996 Mar 28;299 (1-3) :103-12.|[2]Lengyel C, et al. Effect of a neuroprotective drug, eliprodil on cardiac repolarisation: importance of the decreased repolarisation reserve in the development of proarrhythmic risk. Br J Pharmacol. 2004 Sep;143 (1) :152-8.