Puerarin

Puerarin is an isoflavone extracted from Pueraria root and is a 5-HT2C receptor antagonist. Puerarin inhibits the dorsal motor nucleus of the vagus (DMV) -vagus nerve pathway, which in turn leads to decreased fat absorption[1][2][3][4][5].

Product Specifications

CAS Number

[3681-99-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

5-HT Receptor

Type

Natural Products

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Puerarin.html

Purity

98.92

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1C(C2=CC=C(O)C=C2)=COC3=C([C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)C(O)=CC=C13

Molecular Formula

C21H20O9

Molecular Weight

416.38

Precautions

H302, H315, H319, H335

References & Citations

[1]Hu W, et al. Puerarin inhibits iNOS, COX-2 and CRP expression via suppression of NF-κB activation in LPS-induced RAW264.7 macrophage cells. Pharmacol Rep. 2011;63 (3) :781-9.|[2]Zhang H, et al. Puerarin: a novel antagonist to inward rectifier potassium channel (IK1) . Mol Cell Biochem. 2011 Jun;352 (1-2) :117-23.|[3]Zhao L, et al. Protective Effects of Genistein and Puerarin against Chronic Alcohol-Induced Liver Injury in Mice via Antioxidant, Anti-inflammatory, and Anti-apoptotic Mechanisms. J Agric Food Chem. 2016 Sep 28;64 (38) :7291-7.|[4]Pan X, et al. Effect of Puerarin on Expression of ICAM-1 and TNF-α in Kidneys of Diabetic Rats. Med Sci Monit. 2015 Jul 23;21:2134-40.|[5]Lyu, et al. "A brain-to-gut signal controls intestinal fat absorption." Nature (2024) : 1-8.