Vitamin K5

Vitamin K5 (Synkamin) is a photosensitizer and a antimicrobial agent. Vitamin K5 is a specific PKM2 inhibitor with IC50 values of 28, 191 and 120 μM for PKM2, PKM1 and PKL. Vitamin K5 induces apoptosis of colon 26 cells. Vitamin K5 can be used for the research of infection and cancer, and it also can be used as a preservative for pharmaceuticals, foods, and beverages[1][2][3].

Product Specifications

CAS Number

[83-70-5]

Product Name Alternative

Synkamin; Synkamin base

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

Apoptosis; Bacterial; Fungal; Pyruvate Kinase

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/vitamin-k5.html

Solubility

10 mM in DMSO

Smiles

OC1=C2C=CC=CC2=C(N)C=C1C

Molecular Formula

C11H11NO

Molecular Weight

173.21

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Xu F, et al. Vitamin K5 is an efficient photosensitizer for ultraviolet A light inactivation of bacteria. FEMS Microbiol Lett. 2018 Feb 1;365 (4) .|[2]Chen J, et al. Vitamin K (3) and K (5) are inhibitors of tumor pyruvate kinase M2. Cancer Lett. 2012 Mar 28;316 (2) :204-10.|[3]Ogawa M, et al. Vitamins K2, K3 and K5 exert antitumor effects on established colorectal cancer in mice by inducing apoptotic death of tumor cells. Int J Oncol. 2007 Aug;31 (2) :323-31.