Neriifolin

Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na+, K+-ATPase. Neriifolin can target beclin 1, inhibits the formation of LC3-associated phagosomes and ameliorates experimental autoimmune encephalomyelitis (EAE) development. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells[1][2.

Product Specifications

CAS Number

[466-07-9]

Product Name Alternative

17β-Neriifolin

UNSPSC

12352005

Hazard Statement

H300+H310+H330

Target

Apoptosis; Atg8/LC3; Beclin1; Na+/K+ ATPase

Type

Natural Products

Related Pathways

Apoptosis; Autophagy; Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/neriifolin.html

Purity

99.70

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@@]12[C@@]3([H])[C@@](CC[C@@]1([C@](C4=CC(OC4)=O)([H])CC2)C)([H])[C@@]5([C@](C[C@H](CC5)O[C@H]6[C@H]([C@@H]([C@H]([C@@H](O6)C)O)OC)O)([H])CC3)C

Molecular Formula

C30H46O8

Molecular Weight

534.68

Precautions

H300+H310+H330

References & Citations

[1]Keller CW, et al. ATG-dependent phagocytosis in dendritic cells drives myelin-specific CD4+ T cell pathogenicity during CNS inflammation. Proc Natl Acad Sci U S A. 2017;114 (52) :E11228-E11237.|[2]Zhao Q, et al. Neriifolin from seeds of Cerbera manghas L. induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Fitoterapia. 2011;82 (5) :735-741.