Mitoguazone

Mitoguazone (Methylglyoxal-bis (guanylhydrazone) ) is a synthetic polycarbonyl derivative with potent antineoplastic activity. Mitoguazone is a brain-penetrant and competitive S-adenosyl-methionine decarboxylase (SAMDC) inhibitor that disrupts polyamine biosynthesis. Mitoguazone induces cell apoptosis. Mitoguazone inhibits HIV DNA integration into the cellular DNA in both monocytes and macrophages. Mitoguazone has the potential for acute leukemia, Hodgkin's and non-Hodgkin's lymphoma treatment[1][2][3][4].

Product Specifications

CAS Number

[459-86-9]

Product Name Alternative

Methylglyoxal-bis (guanylhydrazone) ; MGBG; Methyl-GAG

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; HIV

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/mitoguazone.html

Purity

99.33

Solubility

DMSO : 5.83 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 50 mg/mL (ultrasonic; adjust pH to 9 with HCl)

Smiles

CC(/C=N/NC(N)=N)=N\NC(N)=N

Molecular Formula

C5H12N8

Molecular Weight

184.20

Precautions

H302, H315, H319, H335

References & Citations

[1]J Rizzo, et al. Pharmacokinetic Profile of Mitoguazone (MGBG) in Patients With AIDS Related non-Hodgkin's Lymphoma. Invest New Drugs. 1996;14 (2) :227-34.|[2]K Davidson, et al. Mitoguazone Induces Apoptosis via a p53-independent Mechanism. Anticancer Drugs. 1998 Aug;9 (7) :635-40.|[3]Xia Jin, et al. Inhibition of HIV Expression and Integration in Macrophages by Methylglyoxal-Bis-Guanylhydrazone. J Virol. 2015 Nov;89 (22) :11176-89.|[4]A M Levine, et al. Mitoguazone Therapy in Patients With Refractory or Relapsed AIDS-related Lymphoma: Results From a Multicenter Phase II Trial. J Clin Oncol. 1997 Mar;15 (3) :1094-103.|[5]R Amlacher, et al. Influence of Leukemia P388 on the Pharmacokinetics of Mitoguazone in B6D2F1 Mice. Pharmazie. 1990 May;45 (5) :364-6.