Prostratin

Prostratin, a natural terpenoid compound, is a PKC activator, with a Ki of 12.5 nM and shows inhibitory effect on HIV-1.

Product Specifications

CAS Number

[60857-08-1]

UNSPSC

12352211

Target

HIV; PKC

Type

Natural Products

Related Pathways

Anti-infection; Epigenetics; TGF-beta/Smad

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/prostratin.html

Purity

99.80

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC(O[C@@]12[C@@]([C@@]3([H])[C@]([C@@H](C2)C)([C@@]4([H])[C@](CC(CO)=C3)(C(C(C)=C4)=O)O)O)([H])C1(C)C)=O

Molecular Formula

C22H30O6

Molecular Weight

390.47

References & Citations

[1]Gustafson KR, et al. A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1. J Med Chem. 1992 May 29;35 (11) :1978-86.|[2]Shen X, et al. The protein kinase C agonist prostratin induces differentiation of human myeloid leukemia cells and enhances cellular differentiation by chemotherapeutic agents. Cancer Lett. 2015 Jan 28;356 (2 Pt B) :686-96.|[3]Wang H, et al. Protein kinase D3 is essential for prostratin-activated transcription of integrated HIV-1 provirus promoter via NF-κB signaling pathway. Biomed Res Int. 2014;2014:968027.