IR-783

IR-783 (ADS 780WS) is a near-infrared (NIR) heptamethine cyanine fluorescent probe. IR-783 significantly inhibits tumour growth and induces apoptosis in MDA-MB-231 xenograft model. IR-783 can be used to study breast cancer[1].

Product Specifications

CAS Number

[115970-66-6]

Product Name Alternative

ADS 780WS

UNSPSC

12171500

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Fluorescent Dye

Type

Dye Reagents

Related Pathways

Apoptosis; Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ir-783.html

Concentration

10mM

Purity

99.87

Solubility

DMSO : 116.67 mg/mL (ultrasonic)

Smiles

O=[S](CCCCN(/C1=C\C=C(CCC2)\C(Cl)=C2/C=C/C(C3(C)C)=[N+](C4=CC=CC=C34)CCCC[S](=O)([O-])=O)C5=CC=CC=C5C1(C)C)(O[Na])=O

Molecular Formula

C38H46ClN2NaO6S2

Molecular Weight

749.35

Precautions

H302, H315, H319, H335

References & Citations

[1]Tang Q, et al. Dynamin-related protein 1-mediated mitochondrial fission contributes to IR-783-induced apoptosis in human breast cancer cells. J Cell Mol Med. 2018 Sep;22 (9) :4474-4485.