CS640

CS640, a chemical probe, is a selective inhibitor of calmodulin-dependent kinases. CS640 inhibits CaMK1D, CaMK1B, CaMK1A, CaMK1G, PIP5K1C, MEK5, RIPK4 and MLK3 with IC50 values of 0.08, 0.03, 0.001, 0.001, 11.2, 0.025, 5.69 and 2.75 μM, respectively. CS640 also shows inhibitory effects to CYP450 2C9 and CYP450 2C19 with IC50 values of 6 and 10 μM, respectively[1].

Product Specifications

CAS Number

[2388506-83-8]

UNSPSC

12352005

Target

CaMK; MEK; Mixed Lineage Kinase

Type

Reference compound

Related Pathways

MAPK/ERK Pathway; Neuronal Signaling

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cs640.html

Purity

96.13

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

NC(C1=CN=C(N2C[C@H](CCC2)N)N=C1NC3=CC(C(C)C)=NC(C(C)C)=C3)=O

Molecular Formula

C21H31N7O

Molecular Weight

397.52

References & Citations

[1]Fromont C, et al. Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity in Vivo Mouse Model. J Med Chem. 2020 Jul 9;63 (13) :6784-6801.