(2R,3R) -E1R

(2R,3R) -E1R (Compound 2b) is an enantiomer of E1R. (2R,3R) -E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders[1].

Product Specifications

CAS Number

[1400888-63-2]

UNSPSC

12352005

Target

Sigma Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/2r-3r-e1r.html

Purity

98.79

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(N)CN1[C@H](C)[C@@H](C2=CC=CC=C2)CC1=O

Molecular Formula

C13H16N2O2

Molecular Weight

232.28

References & Citations

[1]Veinberg G, et al. Synthesis and biological evaluation of 2- (5-methyl-4-phenyl-2-oxopyrrolidin-1-yl) -acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor. Bioorg Med Chem. 2013 May 15;21 (10) :2764-71.