Volinanserin

Volinanserin is a potent and selective antagonist of 5-HT2 receptor, with a Ki of 0.36 nM, and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 and DA D2 receptors. Volinanserin has antipsychotic activity.

Product Specifications

CAS Number

[139290-65-6]

Product Name Alternative

MDL100907; M 100907

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Volinanserin.html

Purity

99.76

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

FC1=CC=C(CCN2CCC([C@@]([H])(O)C3=CC=CC(OC)=C3OC)CC2)C=C1

Molecular Formula

C22H28FNO3

Molecular Weight

373.46

Precautions

H302, H315, H319, H335

References & Citations

[1]Sorensen SM, et al. Characterization of the 5-HT2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: behavioral, electrophysiological and neurochemical studies. J Pharmacol Exp Ther. 1993 Aug;266 (2) :684-91.|[2]Ardayfio PA, et al. The 5-hydroxytryptamine2A receptor antagonist R- (+) -alpha- (2,3-dimethoxyphenyl) -1-[2- (4-fluorophenyl) ethyl-4-piperidinemethanol (M100907) attenuates impulsivity after both drug-induced disruption (dizocilpine) and enhancement (antidepressant drugs) of differential-reinforcement-of-low-rate 72-s behavior in the rat. J Pharmacol Exp Ther. 2008 Dec;327 (3) :891-7.