Drospirenone-d4

Drospirenone-d4 is the deuterium labeled Drospirenone. Drospirenone (Dihydrospirorenone) is a synthetic progestin that is an analog to spironolactone[1][2].

Product Specifications

CAS Number

[2376035-94-6]

Product Name Alternative

Dihydrospirorenone-d4

UNSPSC

12352005

Hazard Statement

H360

Target

Isotope-Labeled Compounds; Progesterone Receptor

Type

Isotope-Labeled Compounds

Related Pathways

Others; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Purity

0.9852

Solubility

10 mM in DMSO

Smiles

C[C@@]12[C@](OC3=O)(C([2H])([2H])C3([2H])[2H])[C@@H](C4)[C@@H]4[C@@]1([H])[C@@]([C@@H]5[C@H]6C5)([H])[C@]([C@](C6=CC7=O)(CC7)C)([H])CC2

Molecular Formula

C24H26D4O3

Molecular Weight

370.52

Precautions

H360

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Fuhrmann, U., et al., The novel progestin drospirenone and its natural counterpart progesterone: biochemical profile and antiandrogenic potential. Contraception, 1996. 54 (4) : p. 243-51.|[3]Muhn, P., et al., Drospirenone: a novel progestogen with antimineralocorticoid and antiandrogenic activity. Pharmacological characterization in animal models. Contraception, 1995. 51 (2) : p. 99-110.|[4]Warming, L., et al., Safety and efficacy of drospirenone used in a continuous combination with 17beta-estradiol for prevention of postmenopausal osteoporosis. Climacteric, 2004. 7 (1) : p. 103-11.