Nimbin

Nimbin is an orally active intermediate limonoid found in Azadirachta. Nimbin prevents tau aggregation and increases cell viability. Nimbin is effective inhibits the envelope protein of dengue virus. Nimbin has anti-inflammatory, antipyretic, antifungal, antihistamine, antiseptic, antioxidant, anti-cancer and anti-viral properties. Nimbin can across blood-brain barrier. Nimbin is promising for research of neurodegenerative diseases and viral infections[1][2][3][4].

Product Specifications

CAS Number

[5945-86-8]

UNSPSC

12352005

Target

Bacterial; Dengue Virus; Flavivirus; Fungal; Histamine Receptor

Type

Natural Products

Related Pathways

Anti-infection; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nimbin.html

Purity

99.59

Solubility

10 mM in DMSO

Smiles

C[C@@]([C@@H]([C@]1(C(C=C2)=O)C)CC(OC)=O)(C3=C4C)[C@@](O[C@]3([H])C[C@@]4([H])C5=COC=C5)([H])[C@@H]([C@@]1([H])[C@]2(C)C(OC)=O)OC(C)=O

Molecular Formula

C30H36O9

Molecular Weight

540.60

References & Citations

[1]Nalini V Gorantla, et al. Neem Derivatives Inhibits Tau Aggregation. J Alzheimers Dis Rep. 2019 Jun 14;3 (1) :169-178.|[2]P Lavanya, et al. Computational Analysis Reveal Inhibitory Action of Nimbin Against Dengue Viral Envelope Protein. Virusdisease. 2015 Dec;26 (4) :243-54.|[3]Li-Juan Yang, et al. Host-guest System of Nimbin and Beta-Cyclodextrin or Its Derivatives: Preparation, Characterization, Inclusion Mode, and Solubilization. J Agric Food Chem. 2010 Aug 11;58 (15) :8545-52.|[4]Sidhu O P, et al. Variability in triterpenoids (nimbin and salanin) composition of neem among different provenances of India[J]. Industrial Crops and Products, 2004, 19 (1) : 69-75.