MI 14

MI 14 is a selective PI4KIIIβ inhibitor with IC50s of 54 nM, >100 μM, >100 μM for PI4KIIIβ, PI4KIIIα, PI4KIIα, respectively. MI 14 has antiviral activity against HCV 1b, CVB3, HRVM, HVC 2a[1].

Product Specifications

CAS Number

[1715934-43-2]

UNSPSC

12352005

Target

HCV; PI4K

Type

Reference compound

Related Pathways

Anti-infection; PI3K/Akt/mTOR

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/mi-14.html

Purity

99.30

Solubility

DMSO : 9.02 mg/mL (ultrasonic; warming)

Smiles

O=C(C)NCCNC1=CC(Cl)=NN2C1=NC(C)=C2C3=CC(S(=O)(N(C)C)=O)=CC=C3

Molecular Formula

C19H23ClN6O3S

Molecular Weight

450.94

References & Citations

[1]Ivana Mejdrová, et al. Highly Selective Phosphatidylinositol 4-Kinase IIIβ Inhibitors and Structural Insight into Their Mode of Action. J Med Chem. 2015 May 14;58 (9) :3767-93.