Germacrone (Standard)
Product Specifications
UNSPSC Description
Germacrone (Standard) is the analytical standard of Germacrone. This product is intended for research and analytical applications. Germacrone is isolated from turmeric and has anti-influenza virus, anti-cancer, and neuroprotective activity. Germacrone inhibits the proliferation of human hepatoma cell lines by downregulating CDK1 and Bcl-2/Bcl-xl and upregulating p21 and Bax, leading to cell cycle arrest in the G2/M phase and apoptosis. Germacrone targets H1N1 and H3N2 influenza A viruses as well as influenza B viruses, significantly reducing viral titers in the lungs in animal models[1][2][3].
Target Antigen
Influenza Virus
Type
Reference Standards
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/germacrone-standard.html
Smiles
O=C1C/C(C)=C/CC/C(C)=C/C/C1=C(C)\C
Molecular Weight
218.33
References & Citations
[1]Liao Q, et al. Germacrone inhibits early stages of influenza virus infection. Antiviral Res. 2013 Dec;100(3):578-88.|[2]Liu Y, et al. Anti-tumor effect of germacrone on human hepatoma cell lines through inducing G2/M cell cycle arrest and promoting apoptosis. Eur J Pharmacol. 2013 Jan 5;698(1-3):95-102.|[3]Wu T, et al. Germacrone attenuates cerebral ischemia/reperfusion injury in rats via antioxidative and antiapoptotic mechanisms. J Cell Biochem. 2019 Nov;120(11):18901-18909.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N0440R/Germacrone-Standard-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N0440R/
CAS Number
6902-91-6
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