Capzimin
Capzimin is a potent and moderately specific proteasome isopeptidase Rpn11 inhibitor.
Product Specifications
CAS Number
[2084868-04-0]
UNSPSC
12352005
Target
Deubiquitinase; Proteasome
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Capzimin.html
Concentration
10mM
Purity
99.19
Solubility
DMSO : ≥ 55.67 mg/mL
Smiles
O=C(C1=CC2=CC=CC(SSC3=C4N=CC(C(NCCC5=NC=CS5)=O)=CC4=CC=C3)=C2N=C1)NCCC6=NC=CS6
Molecular Formula
C30H24N6O2S4
Molecular Weight
628.81
References & Citations
[1]Li J, et al. Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11. Nat Chem Biol. 2017 May;13 (5) :486-493.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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