Prostaglandin A3
Product Specifications
UNSPSC Description
Prostaglandin A3 is a non-enzymatic dehydration product of prostaglandin E3 (PGE3). Prostaglandin A3 showed good affinity for canine EP2 and EP4 receptors with IC50 values of 120 and 20 nM, respectively. The Ki value of Prostaglandin A3 for human PPARγ was 188 μM[1][2][3].
Target Antigen
PPAR; Prostaglandin Receptor
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;GPCR/G Protein;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/prostaglandin-a3.html
Solubility
10 mM in DMSO
Smiles
O=C1[C@@H]([C@H](C=C1)/C=C/[C@H](C/C=C\CC)O)C/C=C\CCCC(O)=O
Molecular Weight
332.43
References & Citations
[1]Hibbs TA, et al. Molecular cloning and characterization of the canine prostaglandin E receptor EP2 subtype. Prostaglandins Other Lipid Mediat. 1999 May;57(2-3):133-47.|[2]Castleberry TA, et al. Molecular cloning and functional characterization of the canine prostaglandin E2 receptor EP4 subtype. Prostaglandins Other Lipid Mediat. 2001 Jul;65(4):167-87.|[3]Ferry G, et al. Binding of prostaglandins to human PPARgamma: tool assessment and new natural ligands. Eur J Pharmacol. 2001 Apr 6;417(1-2):77-89.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-114822/Prostaglandin-A3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-114822/
Clinical Information
No Development Reported
CAS Number
36614-31-0
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