STING agonist-1

STING agonist-1 (G10) is human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) with IC90 of 24.57 μM[1].

Product Specifications

CAS Number

[702662-50-8]

Product Name Alternative

G10

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

STING; Virus Protease

Type

Reference compound

Related Pathways

Anti-infection; Immunology/Inflammation

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/STING-agonist-1.html

Purity

99.93

Solubility

DMSO : 75 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C(SCC(N2CC3=C(F)C=CC=C3Cl)=O)C2=C1)NCC4=CC=CO4

Molecular Formula

C21H16ClFN2O3S

Molecular Weight

430.88

Precautions

H302, H315, H319, H335

References & Citations

[1]Sali TM, et al. Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses. PLoS Pathog. 2015 Dec 8;11 (12) :e1005324.