Nitrofurazone

Nitrofurazone (Nitrofural) is a broad spectrum antibiotic that has oral activity. Nitrofurazone is a nitro-aromatic drug. Nitrofurazone is active against both Gram-positive and Gram-negative bacteria[1][2][3][4][5].

Product Specifications

CAS Number

[59-87-0]

Product Name Alternative

Nitrofural

UNSPSC

12352005

Hazard Statement

H302, H317, H350, H360

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Nitrofurazone.html

Concentration

10mM

Purity

99.83

Solubility

DMSO : ≥ 155 mg/mL

Smiles

O=C(N/N=C/C1=CC=C([N+]([O-])=O)O1)N

Molecular Formula

C6H6N4O4

Molecular Weight

198.14

Precautions

H302, H317, H350, H360

References & Citations

[1]Ryan A, et al. Activation of nitrofurazone by azoreductases: multiple activities in one enzyme. Sci Rep. 2011;1:63.|[2]McCalla DR, et al. Mode of action of nitrofurazone. J Bacteriol. 1970 Dec;104 (3) :1126-34.|[3]Tu Y, et al. Effect of nitrofurazone on bacterial RNA and ribosome synthesis and on the function of ribosomes. Chem Biol Interact. 1976 Jul;14 (1-2) :81-91.|[4]Z Kari FW, et al. Toxicity and carcinogenicity of nitrofurazone in F344/N rats and B6C3F1 mice. Food Chem Toxicol. 1989 Feb;27 (2) :129-37.|[5]Neal RA, et al. The activity of nitrofurazone and furazolidone against Leishmania donovani, L. major and L. enriettii in vitro and in vivo. Ann Trop Med Parasitol. 1988 Oct;82 (5) :453-6.