2-Methoxycinnamaldehyde

2-Methoxycinnamaldehyde (o-Methoxycinnamaldehyde) is a natural compound that can be isolated from Cinnamomum cassia. 2-Methoxycinnamaldehyde inhibits topoisomerase-I/II and NF-κB signaling pathway, causes mitochondrial dysfunction, induces lysosomal vesiculation, thereby leading to DNA damage and cell apoptosis. 2-Methoxycinnamaldehyde exhibits antitumor effects[1][2][3].

Product Specifications

CAS Number

[1504-74-1]

Product Name Alternative

O-Methoxycinnamaldehyde

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Apoptosis; Caspase; Mitochondrial Metabolism; NF-κB; Topoisomerase

Type

Natural Products

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/2-methoxycinnamaldehyde.html

Purity

98.95

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C/C=C/C1=CC=CC=C1OC

Molecular Formula

C10H10O2

Molecular Weight

162.19

Precautions

H315, H319, H335

References & Citations

[1]Wong HY, et al. Cinnamomum verum Component 2-Methoxycinnamaldehyde: A Novel Anticancer Agent with Both Anti-Topoisomerase I and II Activities in Human Lung Adenocarcinoma A549 Cells In Vitro and In Vivo. Phytother Res. 2016 Feb;30 (2) :331-40.|[2]Liu YH, et al. Cinnamomum verum ingredient 2-methoxycinnamaldehyde: a new antiproliferative drug targeting topoisomerase I and II in human lung squamous cell carcinoma NCI-H520 cells. Eur J Cancer Prev. 2017 Jul;26 (4) :314-323.|[3]Jin YH, et al. 2-Methoxycinnamaldehyde inhibits the TNF-α-induced proliferation and migration of human aortic smooth muscle cells. Int J Mol Med. 2017 Jan;39 (1) :191-198.