W1131

W1131 is a potent STAT3 inhibitor, triggering ferroptosis. W1131 suppresses cancer progression in gastric cancer cell subcutaneous xenograft model, organoids model, and PDX model. W1131 effectively alleviates chemical resistance of cancer cells to 5-FU (HY-90006) . W1131 regulates cell cycle, DNA damage response, and oxidative phosphorylation, including IL6-JAK-STAT3 pathway and ferroptosis pathway[1].

Product Specifications

CAS Number

[2740522-79-4]

UNSPSC

12352005

Target

Ferroptosis; Oxidative Phosphorylation; STAT

Type

Reference compound

Related Pathways

Apoptosis; JAK/STAT Signaling; Metabolic Enzyme/Protease; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/w1131.html

Purity

99.45

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=C(C3=CN=C4C=C(C5=CCNCC5)C=CN43)C=C2

Molecular Formula

C23H19N5O4

Molecular Weight

429.43

References & Citations

[1]Ouyang S, et al. Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer. Redox Biol. 2022 Jun;52:102317.