GRK5-IN-2

GRK5-IN-2 (compound 707), a pyridine-based bicyclic compound, is a potent G-protein-coupled receptor kinase 5 (GRK5) inhibitor with an IC50 of 49.7 μM. GRK5-IN-2 regulates the expression and/or release of insulin and is useful for the metabolic disease research[1][2].

Product Specifications

CAS Number

[1642839-27-7]

UNSPSC

12352005

Target

ERK; G Protein-coupled Receptor Kinase (GRK)

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/grk5-in-2.html

Purity

99.91

Solubility

DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

COC1=C(OC)C(OC)=CC(NC2=CC3=C(N=C(C4=CC=CO4)N3C)C=N2)=C1

Molecular Formula

C20H20N4O4

Molecular Weight

380.40

References & Citations

[1]Axel Ullrich (Prof. Dr.), et al. Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators. EP2818472A1.|[2]Key CC, et al., GRK5 is required for adipocyte differentiation through ERK activation. Res Sq [Preprint]. 2024 May 17:rs.3.rs-4360297.