Stearoyl Serotonin
Product Specifications
UNSPSC Description
Stearoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin. Arachidonoyl serotonin is a dual antagonist of fatty acid amide hydrolase (FAAH) and the transient receptor potential vanilloid-type 1 (TRPV1) channel, reducing both acute and chronic peripheral pain. The effects of replacing the arachidonoyl portion with the saturated 18-carbon stearoyl moiety have not been studied. However, replacement of arachidonate with saturated 11- or 12-carbon fatty acids produces compounds that potently inhibit capsaicin-induced TRPV1 channel activation (IC50=0.76 μM) without blocking FAAH-mediated hydrolysis of arachidonoyl ethanolamine (IC50 > 50 μM).
Target Antigen
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/stearoyl-serotonin.html
Smiles
O=C(CCCCCCCCCCCCCCCCC)NCCC1=CNC2=CC=C(C=C12)O
Molecular Weight
442.68
References & Citations
[1]Ortar, et al. New N-arachidonoylserotonin analogues with potential \"dual\" mechanism of action against pain. J. Med. Chem. 50(26), 6554-6569 (2007).
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-121465/Stearoyl-Serotonin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-121465/
Clinical Information
No Development Reported
CAS Number
67964-87-8
Curated Selection
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