Eprosartan

Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active angiotensin II receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensin II receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively [1].

Product Specifications

CAS Number

[133040-01-4]

Product Name Alternative

SKF-108566J (free base)

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Angiotensin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/eprosartan.html

Purity

99.87

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C(C=C1)CN2C(/C=C(CC3=CC=CS3)/C(O)=O)=CN=C2CCCC)O

Molecular Formula

C23H24N2O4S

Molecular Weight

424.51

Precautions

H315, H319

References & Citations

[1]R M Edwards, et al. Pharmacological characterization of the nonpeptide angiotensin II receptor antagonist, SK&F 108566. J Pharmacol Exp Ther. 1992 Jan;260 (1) :175-81.