Aceglutamide

Aceglutamide (α-N-Acetyl-L-glutamine; N2-Acetylglutamine) is a neuroprotectant that can penetrate the blood-brain barrier. Aceglutamide can enhance the antioxidant systems of glutathione (GSH), thioredoxin (Trx) and Nrf2. Aceglutamide also inhibits ASK1 and TRAF1, activates the Akt/Bcl-2 anti-apoptotic pathway, enhances the activity of antioxidant enzymes and reduces oxidative damage. Aceglutamide can improve neurological deficits after cerebral ischemia, reduce infarct volume, and inhibit neuronal apoptosis, especially substantia nigra dopaminergic neurons. Aceglutamide can reduce cerebral ischemia/reperfusion injury, improve motor dysfunction, and is used in ischemic stroke-related research[1][2].

Product Specifications

CAS Number

[2490-97-3]

Product Name Alternative

α-N-Acetyl-L-glutamine; N2-Acetylglutamine

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Akt; Apoptosis; ASK1; Keap1-Nrf2

Type

Natural Products

Related Pathways

Apoptosis; NF-κB; PI3K/Akt/mTOR

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Aceglutamide.html

Purity

98.0

Solubility

DMSO : 16.67 mg/mL (ultrasonic) |H2O : 33.33 mg/mL (ultrasonic)

Smiles

O=C(N)CC[C@@H](C(O)=O)NC(C)=O

Molecular Formula

C7H12N2O4

Molecular Weight

188.18

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhang J, et al. Enhanced thioredoxin, glutathione and Nrf2 antioxidant systems by safflower extract and aceglutamide attenuate cerebral ischaemia/reperfusion injury. J Cell Mol Med. 2020 May;24 (9) :4967-4980.|[2]Zhang R, et al. Neuroprotective effects of Aceglutamide on motor function in a rat model of cerebral ischemia and reperfusion. Restor Neurol Neurosci. 2015;33 (5) :741-59.