Cetrorelix

Cetrorelix is a potent gonadotrophin-releasing hormone (GnRH) antagonist. Cetrorelix inhibits the endogenous luteinizing hormone surge during ovarian stimulation. Cetrorelix reduces cyclophosphamide induced ovarian follicular destruction in mice[1][2].

Product Specifications

CAS Number

[120287-85-6]

Product Name Alternative

SB-75

UNSPSC

12352209

Hazard Statement

H302, H312, H332

Target

GnRH Receptor

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/cetrorelix.html

Purity

99.71

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(N(CCC1)[C@@H]1C(N[C@H](C)C(N)=O)=O)[C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@@H](CCCNC(N)=O)NC([C@@H](NC([C@H](CO)NC([C@H](NC([C@H](NC([C@H](NC(C)=O)CC2=CC3=CC=CC=C3C=C2)=O)CC4=CC=C(Cl)C=C4)=O)CC5=CN=CC=C5)=O)=O)CC6=CC=C(O)C=C6)=O)=O)=O

Molecular Formula

C70H92ClN17O14

Molecular Weight

1431.04

Precautions

H302, H312, H332

References & Citations

[1]Diedrich K, et al. Suppression of the endogenous luteinizing hormone surge by the gonadotrophin-releasing hormone antagonist Cetrorelix during ovarian stimulation. Hum Reprod. 1994 May;9 (5) :788-91. |[2]Meirow D, et al. The GnRH antagonist cetrorelix reduces cyclophosphamide-induced ovarian follicular destruction in mice. Hum Reprod. 2004 Jun;19 (6) :1294-9.