RASF5 rabbit pAb

This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Product Specifications

Background

UniProt

Q8WWW0

Swiss Prot

Q8WWW0

Reactivity

Human; Mouse; Rat

Immunogen

Synthesized peptide derived from human RASF5 AA range: 234-284

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IF; ELISA; IHC

Concentration

1 mg/ml

Dilution

WB 1:500-2000; IF/ICC 1:50-200; ELISA 1:2000-20000; IHC-p 1:50-200

Storage Conditions

-20°C/1 year

Fragment

IgG

Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton. Isoform 2 is mainly located in the perinuclear region of unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A.