ML385

ML385 is a specific nuclear factor erythroid 2-related factor 2 (NRF2) inhibitor with an IC50 of 1.9 μM.

Product Specifications

CAS Number

[846557-71-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Ferroptosis; Keap1-Nrf2

Type

Reference compound

Related Pathways

Apoptosis; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ML385.html

Purity

99.95

Solubility

DMSO : 25 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

O=C(NC1=NC(C2=CC=C(N(C(C3=C(C)C=CC=C3)=O)CC4)C4=C2)=C(C)S1)CC5=CC(OCO6)=C6C=C5

Molecular Formula

C29H25N3O4S

Molecular Weight

511.59

Precautions

H302, H315, H319, H335

References & Citations

[1]Singh A, et al. Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors. ACS Chem Biol. 2016 Nov 18;11 (11) :3214-3225.|[2]Xinnong Liu, et al. Isoliquiritigenin ameliorates acute pancreatitis in mice via inhibition of oxidative stress and modulation of the Nrf2/HO-1 pathway. Oxid Med Cell Longev. 20 March 2018.|[3]Xian P, et al. Mesenchymal stem cell-derived exosomes as a nanotherapeutic agent for amelioration of inflammation-induced astrocyte alterations in mice.Theranostics. 2019 Aug 14;9 (20) :5956-5975.