U-46619

U-46619 (9,11-Methanoepoxy PGH2) is a stable analogue of Thromboxane A2 (HY-113350) (TXA2) and acts as a potent TXA2 (TP) agonist. U-46619 also is a RhoA agonist. U-46619 stimulates the activation of RhoA through TXA2 receptor activation[1][4][5].

Product Specifications

CAS Number

[56985-40-1]

Product Name Alternative

9,11-Methanoepoxy PGH2

UNSPSC

12352005

Hazard Statement

H225, H319, H336

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/u-46619.html

Concentration

28.5 mM * 100 μL in Methyl acetate

Purity

99.79

Solubility

DMSO : 100 mg/mL (ultrasonic; warming)

Smiles

O=C(O)CCC/C=C\C[C@H]1[C@@]2([H])CO[C@@](C2)([H])[C@@H]1/C=C/[C@@H](O)CCCCC

Molecular Formula

C21H34O4

Molecular Weight

350.49

Precautions

H225, H319, H336

References & Citations

[1]Ohkubo S, et al. Thromboxane A2-mediated shape change: independent of Gq-phospholipase C--Ca2+ pathway in rabbit platelets. Br J Pharmacol. 1996 Mar;117 (6) :1095-104.|[2]Su L, et al. The prostaglandin H2 analog U-46619 improves the differentiation efficiency of human induced pluripotent stem cells into endothelial cells by activating both p38MAPK and ERK1/2 signaling pathways. Stem Cell Res Ther. 2018 Nov 15;9 (1) :313.|[3]Schirner M, et al. U 46619 induces different blood pressure effects in male and female spontaneously hypertensive rats (SHR) . Prostaglandins Leukot Essent Fatty Acids. 1993 Jun;48 (6) :469-73.|[4]Chen S, et al. Roles of the RhoA-ROCK Signaling Pathway in the Endothelial H2S Production and Vasodilation in Rat Cerebral Arteries. ACS Omega. 2022 May 20;7 (22) :18498-18508. |[5]Nie D, et al. Thromboxane A2 receptors in prostate carcinoma: expression and its role in regulating cell motility via small GTPase Rho. Cancer Res. 2008 Jan 1;68 (1) :115-21.