CB096

CB096 binds the 5′CGG/3′GGC internal loop structure of r (G4C2) exp RNA, interrupts its gain-of-function mechanism, and thus results in the regulation of nucleolar focusing, RNA splicing defects, RNA metabolism, nucleocytoplasmic transport dysfunction, and toxic dipeptide repeats (DPRs) generated by RNA translation. CB096 inhibits the RAN translation with an IC50 of 20 μM in HEK293T cells[1].

Product Specifications

CAS Number

[108883-90-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cb096.html

Purity

98.72

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC1=CC=C(C2=NC3=CC=C([N+]([O-])=O)C=C3N2)C=C1OC

Molecular Formula

C14H11N3O4

Molecular Weight

285.25

Precautions

H302, H315, H319

References & Citations

[1]Ursu A, et al., Structural Features of Small Molecules Targeting the RNA Repeat Expansion That Causes Genetically Defined ALS/FTD. ACS Chem Biol. 2020 Dec 18;15 (12) :3112-3123.