Methyl pyropheophorbide-a

Methyl pyropheophorbide-a (Pyropheophorbide-a methyl ester), a chlorophyll-a derivative, is a potent photosensitizer that can be used in photodynamic therapy (PDT) of cancer. Methyl pyropheophorbide-a has photodynamic activity and can induce apoptosis and inhibit tumor growth[1][2].

Product Specifications

CAS Number

[6453-67-4]

Product Name Alternative

Pyropheophorbide-a methyl ester

UNSPSC

12352005

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/methyl-pyropheophorbide-a.html

Purity

99.14

Solubility

DMSO : 2.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC1=C(N2)/C=C(C(CC)=C3C)\N=C3/C=C(C(C=C)=C/4C)\NC4=C/C5=N/C([C@H]([C@@H]5C)CCC(OC)=O)=C(C6)\C2=C1C6=O

Molecular Formula

C34H36N4O3

Molecular Weight

548.67

References & Citations

[1]Sun X, et, al. Photodynamic therapy with pyropheophorbide-a methyl ester in human lung carcinoma cancer cell: efficacy, localization and apoptosis. Photochem Photobiol. 2002 Jun;75 (6) :644-51.|[2]Tian Y, et, al. Cell death induced by MPPa-PDT in prostate carcinoma in vitro and in vivo. Biochem Biophys Res Commun. 2006 Sep 22;348 (2) :413-20.