Rat CGRP- (8-37)

Rat CGRP- (8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selective CGRP receptor antagonist.

Product Specifications

CAS Number

[129121-73-9]

UNSPSC

12352209

Target

CGRP Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Rat_CGRP-_8-37_.html

Purity

99.57

Solubility

H2O : 25 mg/mL (ultrasonic)

Smiles

C([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CN=CN2)NC([C@@H](NC([C@H](C(C)C)N)=O)[C@@H](C)O)=O)=O)CCCNC(=N)N)=O)CC(C)C)=O)C)=O)=O)CC(C)C)=O)CC(C)C)=O)CO)=O)CCCNC(=N)N)=O)CO)=O)=O)=O)C(C)C)=O)[C@H](C)C)=O)CCCCN)=O)CC(O)=O)=O)CC(N)=O)=O)=O)C(C)C)(=O)N3[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC4=CC=CC=C4)C(N)=O)=O)C)=O)CCC(O)=O)=O)CO)=O)=O)[C@@H](C)C)=O)CC(N)=O)=O)[C@@H](C)O)=O)CCC3

Molecular Formula

C138H224N42O41

Molecular Weight

3127.51

References & Citations

[1]Bennett AD, et al. Alleviation of mechanical and thermal allodynia by CGRP (8-37) in a rodent model of chroniccentral pain. Pain. 2000 May;86 (1-2) :163-75.|[2]Yu LC, et al. The calcitonin gene-related peptide antagonist CGRP8-37 increases the latency to withdrawalresponses in rats. Brain Res. 1994 Aug 8;653 (1-2) :223-30.