Hydroquinidine

Hydroquinidine (Dihydroquinidine) is a potent ion channel blocker, which exhibits strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells. Hydroquinidine prolongs the QT interval and has antiarrhythmic efficacy[1][2][3][4][5].

Product Specifications

CAS Number

[1435-55-8]

Product Name Alternative

Dihydroquinidine; (+) -Hydroquinidine; Hydroconquinine

UNSPSC

12352005

Hazard Statement

H302

Target

Others

Type

Natural Products

Related Pathways

Others

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Hydroquinidine.html

Purity

99.97

Solubility

DMSO : 20.83 mg/mL (ultrasonic)

Smiles

O[C@@H](C1=CC=NC2=C1C=C(OC)C=C2)[C@]3([H])[N@](C[C@@H]4CC)CC[C@H]4C3

Molecular Formula

C20H26N2O2

Molecular Weight

326.44

Precautions

H302

References & Citations

[1]Mazzanti A, et, al. Hydroquinidine Prevents Life-Threatening Arrhythmic Events in Patients With Short QT Syndrome. J Am Coll Cardiol. 2017 Dec 19;70 (24) :3010-3015.|[2]Hermida JS, et, al. Hydroquinidine therapy in Brugada syndrome. J Am Coll Cardiol. 2004 May 19;43 (10) :1853-60.|[3]Chimienti M, et, al. Comparison of the effectiveness of dihydroquinidine and quinidine on ventricular ectopy after acute and chronic administration. Cardiovasc Drugs Ther. 1988 Dec;2 (5) :679-86.|[4]Mazzanti A, et al. Hydroquinidine Prevents Life-Threatening Arrhythmic Events in Patients With Short QT Syndrome. J Am Coll Cardiol. 2017 Dec 19;70 (24) :3010-3015. |[5]Yavuz M, et al. A potent ion channel blocker, hydroquinidine, exhibits strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells. Mol Biol Rep. 2023 Mar;50 (3) :2611-2621.