Hexadecanamide

Hexadecanamide (Palmitamide) is a fatty acid amide that has orally active anti-allergic, antioxidant, and neuroprotective effects. Hexadecanamide exerts protective effects in Staphylococcus aureus- and SARA-induced mastitis. Hexadecanamide suppresses S. aureus-induced activation of the NF-κB pathway and improves blood-milk barrier integrity. Hexadecanamide activates PPARα. Hexadecanamide enhances sperm motility in vitro. Hexadecanamide can be studied in research for mastitis and asthenozoospermia[1][2].

Product Specifications

CAS Number

[629-54-9]

Product Name Alternative

Palmitamide

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; NF-κB; PPAR

Type

Natural Products

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/hexadecanamide.html

Purity

97.0

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

NC(CCCCCCCCCCCCCCC)=O

Molecular Formula

C16H33NO

Molecular Weight

255.44

Precautions

H302, H315, H319, H335

References & Citations

[1]Bao L, et al. Hexadecanamide alleviates Staphylococcus aureus-induced mastitis in mice by inhibiting inflammatory responses and restoring blood-milk barrier integrity. PLoS Pathog. 2023 Nov 10;19 (11) :e1011764.|[2]Han B, et al. Changes in seminal plasma microecological dynamics and the mechanistic impact of core metabolite hexadecanamide in asthenozoospermia patients. Imeta. 2024 Jan 25;3 (2) :e166. https://pubmed.ncbi.nlm.nih.gov/38882497/