Iclepertin

Iclepertin (BI-425809) is a potent, selective and orally active glycine transporter 1 (GlyT1) inhibitor. Iclepertin is inactive against GlyT2. Iclepertin can be used for Alzheimer disease and schizophrenia research[1].

Product Specifications

CAS Number

[1421936-85-7]

Product Name Alternative

BI-425809

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GlyT

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bi-425809.html

Purity

99.97

Solubility

DMSO : 11.36 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=C(C=CC(S(C)(=O)=O)=C1)O[C@H](C)C(F)(F)F)N2C[C@]3(C4=NOC(C(F)(F)F)=C4)[C@@](C2)([H])C3

Molecular Formula

C20H18F6N2O5S

Molecular Weight

512.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Holger Rosenbrock, et al. Evaluation of Pharmacokinetics and Pharmacodynamics of BI 425809, a Novel GlyT1 Inhibitor: Translational Studies. Clin Transl Sci. 2018 Nov;11 (6) :616-623.