Chloropyramine hydrochloride

Chloropyramine hydrochloride is a histamine receptor H1 antagonist which can also inhibit the biochemical function of VEGFR-3 and FAK.

Product Specifications

CAS Number

[6170-42-9]

UNSPSC

12352005

Hazard Statement

H302, H312, H315, H319, H332

Target

FAK; Histamine Receptor; VEGFR

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Chloropyramine_hydrochloride.html

Purity

99.64

Solubility

DMSO : 30 mg/mL (ultrasonic; warming) |H2O : 100 mg/mL (ultrasonic)

Smiles

CN(C)CCN(CC1=CC=C(Cl)C=C1)C2=NC=CC=C2.[H]Cl

Molecular Formula

C16H21Cl2N3

Molecular Weight

326.26

Precautions

H302, H312, H315, H319, H332

References & Citations

[1]Kurenova EV, et al. Small molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo. J Med Chem. 2009 Aug 13;52 (15) :4716-24.